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Cognitive decline from estimated premorbid status predicts neurodegeneration in Alzheimer's disease
Stockholm University, Faculty of Social Sciences, Department of Psychology. KI, Stockholm, Sweden.
2009 (English)In: Neuropsychology, ISSN 0894-4105, E-ISSN 1931-1559, Vol. 23, no 1, 117-124 p.Article in journal (Refereed) Published
Abstract [en]

This study investigated the relationship between premorbid and current cognitive function with respect to the clinical features of patients with various types of neurodegeneration in the form of Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive impairment (SCI), as compared with a healthy control group (C). Clinical features (MMSE, cognitive and depressive symptoms), genetics (apolipoprotein E; APOE) and measures of neurodegeneration (Aβ-sub(42), t-tau, and p-tau) were examined, as well as present cognitive function. Various methods of assessing premorbid cognitive function were compared, including a Swedish NART-analogous test (Irregularly Spelled Words; ISW), a Swedish lexical decision test (SLDT), a Hold test (Information in WAIS-R), Best current performance test, and combined demographic characteristics. Results showed that cognitive decline (premorbid minus current cognitive function) based on SLDT and ISW was a significant predictor for MMSE and Aβ-sub(42), whereas corresponding associations for present cognitive function and decline measures based on other methods were less powerful. Results also showed that specific verbal abilities (e.g., SLDT and ISW) were insensitive to AD and that these abilities indicated premorbid cognitive function in retrospect. In conclusion, cognitive decline from premorbid status reflects the disease processes.

Place, publisher, year, edition, pages
American Psychological Association , 2009. Vol. 23, no 1, 117-124 p.
Keyword [en]
premorbid function, cognitive function, Alzheimer's disease
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Research subject
URN: urn:nbn:se:su:diva-27635DOI: 10.1037/a0014074ISI: 000262209300012PubMedID: 19210039OAI: diva2:216658
Available from: 2009-05-11 Created: 2009-05-11 Last updated: 2015-09-04Bibliographically approved

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Almkvist, Ove
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