Change search
ReferencesLink to record
Permanent link

Direct link
Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder
Karolinska Institutet.
Karolinska Institutet.
Stockholm University, Faculty of Social Sciences, Department of Psychology. Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet.
Show others and affiliations
2009 (English)In: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 50, no 1, 5-10 p.Article in journal (Refereed) Published
Abstract [en]

The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Forty-two women with BPD and a history of suicide attempts were genotyped, and the frequency of a TPH-1 haplotype previously uniquely associated with BPD was calculated. The BPD group scored significantly lower than a control group in the IGT. Furthermore, the TPH-1 haplotype displayed a significantly higher frequency in BPD participants with impaired decision making, compared to BPD participants with normal scores. These findings suggest that impaired decision-making as determined by the IGT is a feature of BPD and may be (i) associated with serotonin dysfunction, and (ii) possibly relevant for suicidal behavior.

Place, publisher, year, edition, pages
Wiley , 2009. Vol. 50, no 1, 5-10 p.
Keyword [en]
borderline personality disorder, tryptophan hydroxylase-1 gene, serotonin, decision-making, Iowa Gambling Task
National Category
Research subject
URN: urn:nbn:se:su:diva-27716DOI: 10.1111/j.1467-9450.2008.00689.xISI: 000262487700003OAI: diva2:217259

This study was financially supported by grants from the Stockholm County Council, the Swedish Science Council, the AFA Insurance Company and by funds from the Karolinska Institute.

Available from: 2009-05-13 Created: 2009-05-13 Last updated: 2015-09-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Wiens, Stefan
By organisation
Department of Psychology
In the same journal
Scandinavian Journal of Psychology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 26 hits
ReferencesLink to record
Permanent link

Direct link