Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder
2009 (English)In: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 50, no 1, 5-10 p.Article in journal (Refereed) Published
The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Forty-two women with BPD and a history of suicide attempts were genotyped, and the frequency of a TPH-1 haplotype previously uniquely associated with BPD was calculated. The BPD group scored significantly lower than a control group in the IGT. Furthermore, the TPH-1 haplotype displayed a significantly higher frequency in BPD participants with impaired decision making, compared to BPD participants with normal scores. These findings suggest that impaired decision-making as determined by the IGT is a feature of BPD and may be (i) associated with serotonin dysfunction, and (ii) possibly relevant for suicidal behavior.
Place, publisher, year, edition, pages
Wiley , 2009. Vol. 50, no 1, 5-10 p.
borderline personality disorder, tryptophan hydroxylase-1 gene, serotonin, decision-making, Iowa Gambling Task
Research subject Psychology
IdentifiersURN: urn:nbn:se:su:diva-27716DOI: 10.1111/j.1467-9450.2008.00689.xISI: 000262487700003OAI: oai:DiVA.org:su-27716DiVA: diva2:217259
This study was financially supported by grants from the Stockholm County Council, the Swedish Science Council, the AFA Insurance Company and by funds from the Karolinska Institute.2009-05-132009-05-132015-09-04Bibliographically approved