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Effect of Local Anesthetic Lidocaine on Electrostatic Properties of a Lipid Bilayer
Stockholm University, Faculty of Science, Department of Physical, Inorganic and Structural Chemistry. Stockholm University, Faculty of Science, Department of Physical, Inorganic and Structural Chemistry, Physical Chemistry.
Stockholm University, Faculty of Science, Department of Physical, Inorganic and Structural Chemistry, Physical Chemistry. (computational chemistry)
2008 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 94, 525-531 p.Article in journal (Refereed) Published
Abstract [en]

The influence of local anesthetic lidocaine on electrostatic properties of a lipid membrane bilayer was studied by molecular dynamics simulations. The electrostatic dipole potential, charge densities, and orientations of the headgroup angle have been examined in presence of different amounts of charged or uncharged forms of lidocaine. Important differences of the membrane properties caused by the presence of the both forms of lidocaine are presented and discussed. Our simulations have shown that both charged and uncharged lidocaine cause almost the same increase of the dipole electrostatic potential in the middle of membrane though for different reasons. The increase, being about 90 mV for 9 mol % of lidocaine and 220 mV for 28 mol% of lidocaine, is of the size which may affect the functioning of voltage-gated ion channels.

Place, publisher, year, edition, pages
2008. Vol. 94, 525-531 p.
Keyword [en]
membranes; DMPC; lidocaine; molecular dynamics; electrostatics
National Category
Physical Chemistry
Research subject
Physical Chemistry
Identifiers
URN: urn:nbn:se:su:diva-28982DOI: doi:10.1529/biophysj.107.104208ISI: 000251924200022OAI: oai:DiVA.org:su-28982DiVA: diva2:228402
Projects
Advanced computer simulation methods for theoretical description of molecular systems
Available from: 2010-11-26 Created: 2009-07-30 Last updated: 2017-12-13Bibliographically approved

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Högberg, Carl-JohanLyubartsev, Alexander
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