Effect of Local Anesthetic Lidocaine on Electrostatic Properties of a Lipid Bilayer
2008 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 94, 525-531 p.Article in journal (Refereed) Published
The influence of local anesthetic lidocaine on electrostatic properties of a lipid membrane bilayer was studied by molecular dynamics simulations. The electrostatic dipole potential, charge densities, and orientations of the headgroup angle have been examined in presence of different amounts of charged or uncharged forms of lidocaine. Important differences of the membrane properties caused by the presence of the both forms of lidocaine are presented and discussed. Our simulations have shown that both charged and uncharged lidocaine cause almost the same increase of the dipole electrostatic potential in the middle of membrane though for different reasons. The increase, being about 90 mV for 9 mol % of lidocaine and 220 mV for 28 mol% of lidocaine, is of the size which may affect the functioning of voltage-gated ion channels.
Place, publisher, year, edition, pages
2008. Vol. 94, 525-531 p.
membranes; DMPC; lidocaine; molecular dynamics; electrostatics
Research subject Physical Chemistry
IdentifiersURN: urn:nbn:se:su:diva-28982DOI: doi:10.1529/biophysj.107.104208ISI: 000251924200022OAI: oai:DiVA.org:su-28982DiVA: diva2:228402
ProjectsAdvanced computer simulation methods for theoretical description of molecular systems