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Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila.
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2009 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 106, no 31, 13070-13075 p.Article in journal (Refereed) Published
Abstract [en]

The role of classical neurotransmitters in the transfer and processing of olfactory information is well established in many organisms. Neuropeptide action, however, is largely unexplored in any peripheral olfactory system. A subpopulation of local interneurons (LNs) in the Drosophila antannal lobe is peptidergic, expressing Drosophila tachykinins (DTKs). We show here that olfactory receptor neurons (ORNs) express the DTK receptor (DTKR). Using two-photon microscopy, we found that DTK applied to the antennal lobe suppresses presynaptic calcium and synaptic transmission in the ORNs. Furthermore, reduction of DTKR expression in ORNs by targeted RNA interference eliminates presynaptic suppression and alters olfactory behaviors. We detect opposite behavioral phenotypes after reduction and over expression of DTKR in ORNs. Our findings suggest a presynaptic inhibitory feedback to ORNs from peptidergic LNs in the antennal lobe.

Place, publisher, year, edition, pages
2009. Vol. 106, no 31, 13070-13075 p.
Keyword [en]
olfactory behavior, presynaptic inhibition, tachykinin, two-photon imaging
National Category
Neurosciences
Research subject
Neurochemistry and Molecular Neurobiology
Identifiers
URN: urn:nbn:se:su:diva-30314DOI: 10.1073/pnas.0813004106ISI: 000268667600090OAI: oai:DiVA.org:su-30314DiVA: diva2:271424
Available from: 2009-10-12 Created: 2009-10-12 Last updated: 2017-12-12Bibliographically approved

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Nässel, Dick RWinther, Åsa M E
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