Change search
ReferencesLink to record
Permanent link

Direct link
Tachykinin-related peptides modulate odor perception and locomotoractivity in Drosophila
Stockholm University, Faculty of Science, Department of Zoology, Functional Morphology. (Åsa Winther)
2006 (English)In: Molecular and Cellular Neuroscience, ISSN 1044-7431, E-ISSN 1095-9327, Vol. 31, no 3, 399-406 p.Article in journal (Refereed) Published
Abstract [en]

The invertebrate tachykinin-related peptides (TKRPs) constitute aconserved family, structurally related to the mammalian tachykinins,including members such as substance P and neurokinins A and B.Although their expression has been documented in the brains of insectsand mammals, their neural functions remain largely unknown,particularly in behavior. Here, we have studied the role of TKRPs inDrosophila. We have analyzed the olfactory perception and thelocomotor activity of individuals in which TKRPs are eliminated inthe nervous system specifically, by using RNAi constructs to silencegene expression. The perception of specific odorants and concentrationsis modified towards a loss of sensitivity, thus resulting in asignificant change of the behavioral response towards indifference. Inlocomotion assays, the TKRP-deficient flies show hyperactivity. Weconclude that these peptides are modulators of olfactory perceptionand locomotion activity in agreement with their abundant expression inthe olfactory lobes and central complex. In these brain centers, TKRPsseem to enhance the regulatory inhibition of the neurons in which theyare expressed.

Place, publisher, year, edition, pages
2006. Vol. 31, no 3, 399-406 p.
Keyword [en]
Neuropeptide, RNA interference, Antennal lobe, Central body complex, Olfaction, Locomotion
National Category
URN: urn:nbn:se:su:diva-30325DOI: 10.1016/j.mcn.2005.10.010OAI: diva2:271468
Available from: 2009-10-12 Created: 2009-10-12 Last updated: 2011-11-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Winther, Åsa M E
By organisation
Functional Morphology
In the same journal
Molecular and Cellular Neuroscience

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 39 hits
ReferencesLink to record
Permanent link

Direct link