Fine-tuning catalytic activity and selectivity-[Rh(amino acid thioamide)] complexes for efficient ketone reduction
2009 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 50, no 46, 6321-6324 p.Article in journal (Refereed) Published
Amino acid-derived thioamides are prepared and evaluated as ligands in the rhodium-catalyzed asymmetric transfer hydrogenation of ketones in 2-propanol. It is found that increasing the steric bulk at the C-terminus of the ligand had a positive impact on both activity and selectivity in the reduction reaction. In order to find the optimum catalyst, a study is performed on a series of thioamide ligands having substituents of varying size.
Place, publisher, year, edition, pages
2009. Vol. 50, no 46, 6321-6324 p.
IdentifiersURN: urn:nbn:se:su:diva-31031DOI: 10.1016/j.tetlet.2009.08.116ISI: 000271055100027OAI: oai:DiVA.org:su-31031DiVA: diva2:274809