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Age-related loss of olfactory sensitivity: Association to dopamine transporter binding in putamen
Stockholm University, Faculty of Social Sciences, Department of Psychology, Perception and psychophysics. Stockholm Brain Institute, Stockholm, Sweden.
Karolinska Institutet.
University of Dresden Medical School.
University of Dresden Medical School.
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2009 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 161, no 2, 422-426 p.Article in journal (Refereed) Published
Abstract [en]

The relationship between age-related reductions in the binding potential for the striatal dopamine transporter (DAT) and age-related deficits in olfactory sensitivity was examined in 12 subjects ranging from 36 to 82 years of age. Positron emission tomography (PET) and the radioligand [11C]β-CIT-FE were used to determine DAT binding in two striatal regions, the caudate and the putamen. The results showed age-related losses of DAT binding from early to late adulthood of similar size for caudate and putamen, and there was a pronounced age deterioration in olfactory sensitivity. Importantly, the age-related olfactory deficit was associated with reductions in DAT binding in putamen, but not caudate. Also, DAT binding in putamen added systematic variance in odor threshold after controlling for age. The findings indicate that DAT binding in putamen is related to age-related olfactory deficits, as well as to odor sensitivity independently of age.

Place, publisher, year, edition, pages
Elsevier Ltd. , 2009. Vol. 161, no 2, 422-426 p.
Keyword [en]
olfaction, dopamine, striatum, putamen, aging
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Research subject
URN: urn:nbn:se:su:diva-31807DOI: 10.1016/j.neuroscience.2009.03.074ISI: 000266794100010OAI: diva2:278634

The present research was supported by grants from the Swedish Research Council to Maria Larsson, and by grants from the Swedish Research Council and Swedish Brain Power to Lars Bäckman.

Available from: 2009-11-27 Created: 2009-11-27 Last updated: 2016-06-22Bibliographically approved

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