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The Role of Adhesion in Arthropod Immune Recognition
Stockholm University, Faculty of Science, Department of Molecular Biology and Functional Genomics.
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
2010 (English)In: Annual review of entomology, ISSN 1545-2948, Vol. 55, 485-504 p.Article in journal (Refereed) Published
Abstract [en]

The recognition and inactivation of toxins and pathogens are mediated by a combination of cell-free and cellular mechanisms. A number of soluble and membrane-bound pattern recognition molecules interact with elicitors to become involved in both cell-free inactivation as well as cellular uptake reactions. Here we describe the possible recognition and effector function of key arthropod immune proteins, such as peroxinectin, hemolin, and hemomucin, as an outcome of changes in adhesiveness, which drive self-assembly reactions leading to cell-free coagulation and cellular uptake reactions. The fact that some of these proteins are essential for immune and developmental functions in some species, but not found in closely related species, may point to the existence of multiprotein assemblies, which are conserved at the mechanistic level and can function with more than one combination of protein constituents. Expected final online publication date for the Annual Review of Entomology Volume 55 is December 03, 2009. Please see for revised estimates.

Place, publisher, year, edition, pages
Palo Alto, 2010. Vol. 55, 485-504 p.
Keyword [en]
innate immune recognition; peroxinectin; hemolin; hemomucin; lipophorin particles; coagulation; phenoloxidase activating cascade
National Category
Natural Sciences
Research subject
URN: urn:nbn:se:su:diva-31987DOI: 10.1146/annurev.ento.54.110807.090618ISI: 000273712100025PubMedID: 19743913OAI: diva2:279140
Available from: 2009-12-01 Created: 2009-12-01 Last updated: 2013-10-07Bibliographically approved

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Theopold, UlrichFaye, Ingrid
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Department of Molecular Biology and Functional GenomicsDepartment of Genetics, Microbiology and Toxicology
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