Change search
ReferencesLink to record
Permanent link

Direct link
Estimation of systemic toxicity of acrylamide by integration of in vitro toxicity data with kinetic simulations.
Stockholm University, Faculty of Science, Department of Neurochemistry.
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-6298-201X
1999 (English)In: Toxicology and Applied Pharmacology, ISSN 0041-008X, Vol. 158, no 3, 261-268 p.Article in journal (Refereed) Published
Abstract [en]

Neurodegenerative properties of acrylamide were studied in vitro by exposure of differentiated SH-SY5Y human neuroblastoma cells for 72 h. The number of neurites per cell and the total cellular protein content were determined every 24 h throughout the exposure and the subsequent 96-h recovery period. Using kinetic data on the metabolism of acrylamide in rat, a biokinetic model was constructed in which the in vitro toxicity data were integrated. Using this model, we estimated the acute and subchronic toxicity of acrylamide for the rat in vivo. These estimations were compared to experimentally derived lowest observed effect doses (LOEDs) for daily intraperitoneal exposure (1, 10, 30, and 90 days) to acrylamide. The estimated LOEDs differed maximally twofold from the experimental LOEDs, and the nonlinear response to acrylamide exposure over time was simulated correctly. It is concluded that the integration of the present in vitro toxicity data with kinetic data gives adequate estimates of acute and subchronic neurotoxicity resulting from acrylamide exposure.

Place, publisher, year, edition, pages
1999. Vol. 158, no 3, 261-268 p.
URN: urn:nbn:se:su:diva-32625DOI: 10.1006/taap.1999.8670PubMedID: 10438659OAI: diva2:281136
Available from: 2009-12-14 Created: 2009-12-14 Last updated: 2015-03-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Forsby, A
By organisation
Department of Neurochemistry
In the same journal
Toxicology and Applied Pharmacology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 13 hits
ReferencesLink to record
Permanent link

Direct link