Change search
ReferencesLink to record
Permanent link

Direct link
Hypoxia-independent angiogenesis in adipose tissues during cold acclimation.
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Physiology.
Show others and affiliations
2009 (English)In: Cell Metabolism, ISSN 1550-4131, Vol. 9, no 1, 99-109 p.Article in journal (Refereed) Published
Abstract [en]

The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. Here, we show that exposure of mice to cold led to activation of angiogenesis in both white and brown adipose tissues. In the inguinal depot, cold exposure resulted in elevated expression levels of brown-fat-associated proteins, including uncoupling protein-1 (UCP1) and PGC-1alpha. Proangiogenic factors such as VEGF were upregulated, and endogenous angiogenesis inhibitors, including thrombospondin, were downregulated. In wild-type mice, the adipose tissues became hypoxic during cold exposure; in UCP1(-/-) mice, hypoxia did not occur, but, remarkably, the augmented angiogenesis was unaltered and was thus hypoxia independent. Intriguingly, VEGFR2 blockage abolished the cold-induced angiogenesis and significantly impaired nonshivering thermogenesis capacity. Unexpectedly, VEGFR1 blockage resulted in the opposite effects: increased adipose vascularity and nonshivering thermogenesis capacity. Our findings have conceptual implications concerning application of angiogenesis modulators for treatment of obesity and metabolic disorders.

Place, publisher, year, edition, pages
2009. Vol. 9, no 1, 99-109 p.
National Category
Cell Biology
Research subject
URN: urn:nbn:se:su:diva-32904DOI: 10.1016/j.cmet.2008.11.009ISI: 000262333000013PubMedID: 19117550OAI: diva2:281915
Available from: 2009-12-17 Created: 2009-12-17 Last updated: 2011-09-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Petrovic, NatasaNedergaard, JanCannon, Barbara
By organisation
In the same journal
Cell Metabolism
Cell Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 93 hits
ReferencesLink to record
Permanent link

Direct link