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Thermogenesis challenges the adipostat hypothesis for body-weight control.
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Physiology.
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Physiology.
2009 (English)In: Proceedings of the Nutrition Society, ISSN 0029-6651, E-ISSN 1475-2719, Vol. 68, no 4, 401-7 p.Article in journal (Refereed) Published
Abstract [en]

According to the adipostat hypothesis for body-weight control, alterations in body weight should always be compensated by adequate alterations in food intake and thermogenesis. Thus, increased thermogenesis should not be able to counteract obesity because food intake would be increased. However evidence is presented here that thermogenesis in different forms (through artificial uncouplers, exercise, cold exposure) may counteract obesity and is not always fully compensated by increased food intake. Correspondingly, a decreased capacity for metaboloregulatory thermogenesis (i.e. non-functional brown adipose tissue) may in itself lead to obesity. This is evident in mice and may be valid for human subjects, as a substantial proportion of adults possess brown adipose tissue, and those with less or without brown adipose tissue would seem to be more prone to obesity. Thus, increased thermogenesis may counteract obesity, without dietary intervention.

Place, publisher, year, edition, pages
2009. Vol. 68, no 4, 401-7 p.
National Category
Physiology
Research subject
Physiology; Physiology
Identifiers
URN: urn:nbn:se:su:diva-32934DOI: 10.1017/S0029665109990255ISI: 000271732800008PubMedID: 19775494OAI: oai:DiVA.org:su-32934DiVA: diva2:281994
Available from: 2009-12-18 Created: 2009-12-18 Last updated: 2011-07-12Bibliographically approved

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