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Allergic women have reduced sHLA-G plasma levels at delivery.
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
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2009 (English)In: American Journal of Reproductive Immunology, ISSN 8755-8920, Vol. 61, no 5, 368-76 p.Article in journal (Refereed) Published
Abstract [en]

PROBLEM: HLA-G antigen maintains a tolerogenic condition at the foeto-maternal interface, counteracts inflammation in autoimmune diseases and soluble HLA-G (sHLA-G) levels decrease in allergic-asthmatics. Taking into consideration these findings, we analyzed if sHLA-G and interleukin-10 (IL-10) could be influenced by pregnancy and labour in allergic and non-allergic women. METHOD OF STUDY: sHLA-G isoforms and IL-10 levels were determined in the plasma samples of 43 women (15 non-allergic, 28 allergic) during third trimester, at delivery and 2 years after pregnancy by immunoenzymatic assays. RESULTS: A significant increase in sHLA-G and IL-10 levels was documented at delivery in both allergic and non-allergic women. Allergic women showed lower sHLA-G concentrations. sHLA-G1 was evidenced as the predominant plasma isoform. CONCLUSION: The data showed increased sHLA-G and IL-10 concentrations at delivery, regardless of the allergic status. The sHLA-G1 isoform is mainly responsible for the increased sHLA-G levels at delivery.

Place, publisher, year, edition, pages
2009. Vol. 61, no 5, 368-76 p.
Keyword [en]
Delivery, HLA-G5, plasma, sHLA-G1
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Research subject
URN: urn:nbn:se:su:diva-32994DOI: 10.1111/j.1600-0897.2009.00703.xISI: 000264823300007PubMedID: 19341387OAI: diva2:282127
Available from: 2009-12-18 Created: 2009-12-18 Last updated: 2011-08-24Bibliographically approved

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