Early-life EBV infection protects against persistent IgE sensitization.
2010 (English)In: The Journal of allergy and clinical immunology, ISSN 1097-6825, Vol. 125, no 2, 433-8 p.Article in journal (Refereed) Published
BACKGROUND: Infection with EBV has previously been implicated in influencing allergic disorders, but its precise role remains contradictory. The timing of primary infection may contribute to the discrepancies. OBJECTIVE: This study aimed at investigating whether the time-point of primary EBV infection during childhood could be of importance in modulating the risk of developing IgE sensitization. METHODS: A total of 219 Swedish infants were followed prospectively to 5 years of age with clinical examinations, skin prick testing, specific IgE analyses, and determination of serostatus against EBV. RESULTS: After analysis of the children's EBV serostatus, we found that 5-year-olds who were infected with EBV before the age of 2 years were at a significantly lower risk of being persistently IgE-sensitized-that is, sensitized at both 2 and 5 years of age (adjusted odds ratio, 0.34; 95% CI, 0.12-0.94). In contrast, contraction of EBV after 2 years of age was highly associated with late-onset IgE sensitization (adjusted odds ratio, 4.64; 95% CI, 1.57-13.69). Persistently sensitized 5-year-olds had higher specific-IgE levels than children with late-onset IgE sensitization (P < .01). CONCLUSION: Our data support the value of early-life microbial exposure for protection against the development of IgE sensitization and underscore the proximate postnatal years as an important period during which EBV could contribute to an allergo-protective immune profile.
Place, publisher, year, edition, pages
2010. Vol. 125, no 2, 433-8 p.
IdentifiersURN: urn:nbn:se:su:diva-33003DOI: 10.1016/j.jaci.2009.09.033PubMedID: 19963258OAI: oai:DiVA.org:su-33003DiVA: diva2:282153