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Reduced activity of glutamine synthetase in Rhodospirillum rubrum mutants lacking the adenylyltransferase GlnE
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2009 (English)In: Research in Microbiology, ISSN 0923-2508, Vol. 160, no 8, 581-4 p.Article in journal (Refereed) Published
Abstract [en]

In the nitrogen-fixing bacterium Rhodospirillum rubrum, the GlnE adenylyltransferase (encoded by glnE) catalyzes reversible adenylylation of glutamine synthetase, thereby regulating nitrogen assimilation. We have generated glnE mutant strains that are unable to adenylylate glutamine synthetase (GS). Surprisingly, the activity of GS was lower in the mutants than in the wild type, even when grown in nitrogen-fixing conditions. Our results support the proposal that R. rubrum can only cope with the absence of an adenylylation system in the presence of lowered GS expression or activity. In general terms, this report also provides further support for the central role of GS in bacterial metabolism.

Place, publisher, year, edition, pages
2009. Vol. 160, no 8, 581-4 p.
Keyword [en]
Rhodospirillum rubrum, Adenylyltransferase, Glutamine synthetase, glnE
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:su:diva-33828DOI: 10.1016/j.resmic.2009.09.003ISI: 000272117600008PubMedID: 19761831OAI: oai:DiVA.org:su-33828DiVA: diva2:283700
Available from: 2009-12-30 Created: 2009-12-30 Last updated: 2015-06-25Bibliographically approved

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Nordlund, StefanTeixeira, Pedro Filipe
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