Change search
ReferencesLink to record
Permanent link

Direct link
Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors.
Stockholm University, Faculty of Science, Department of Neurochemistry.
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0002-0308-1964
2009 (English)In: Cellular and molecular life sciences : CMLS, ISSN 1420-9071, Vol. 66, no 14, 2299-2318 p.Article in journal (Refereed) Published
Abstract [en]

The Alzheimer's amyloid precursor protein (APP) belongs to a conserved gene family that also includes the mammalian APLP1 and APLP2, the Drosophila APPL, and the C. elegans APL-1. The biological function of APP is still not fully clear. However, it is known that the APP family proteins have redundant and partly overlapping functions, which demonstrates the importance of studying all APP family members to gain a more complete picture. When APP was first cloned, it was speculated that it could function as a receptor. This theory has been further substantiated by studies showing that APP and its homologues bind both extracellular ligands and intracellular adaptor proteins. The APP family proteins undergo regulated intramembrane proteolysis (RIP), generating secreted and cytoplasmic fragments that have been ascribed different functions. In this review, we will discuss the APP family with focus on biological functions, binding partners, and regulated processing.

Place, publisher, year, edition, pages
2009. Vol. 66, no 14, 2299-2318 p.
URN: urn:nbn:se:su:diva-34358DOI: 10.1007/s00018-009-0020-8ISI: 000267886500008PubMedID: 19333550OAI: diva2:284593
Available from: 2010-01-07 Created: 2010-01-07 Last updated: 2015-03-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Jacobsen, Kristin TIverfeldt, Kerstin
By organisation
Department of Neurochemistry

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 27 hits
ReferencesLink to record
Permanent link

Direct link