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APOE and lipid level synergy effects on declarative memory functioning in adulthood
Stockholm University, Faculty of Social Sciences, Department of Psychology.
Stockholm University, Faculty of Social Sciences, Department of Psychology.
Stockholm Brain Institute.
Umeå universitet.
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2009 (English)In: European Psychologist, ISSN 1016-9040, E-ISSN 1878-531X, Vol. 14, no 4, 268-278 p.Article in journal (Refereed) Published
Abstract [en]

This study of the general population examined interactions of the gene Apolipoprotein E (APOE) and/or lipid levels, and their effects on cognitive change. A MANCOVA model based on longitudinal data (with a 5 year follow-up) obtained from the Betula study (n = 1777; age 35–85 years) was used. The significant two-way and three-way interaction effects detected were equally frequent in tests of episodic and semantic memory. A difference in the distribution of interaction effects on episodic and semantic memory decline was also found. Men demonstrated the worst cognitive development as shown by significant two-way interaction effects on episodic memory whereas two-way interaction effects among women resulted in the worst semantic memory development. This result is discussed from the viewpoint that tests of episodic and semantic memory have different cognitive demands. This study focuses on how interaction effects of the gene APOE and vascular risk factors (such as lipid levels) affect cognitive abilities and also whether the interaction effects vary across age and sex. In this study, the main focus is on interaction effects as a phenomenon in itself.

Place, publisher, year, edition, pages
2009. Vol. 14, no 4, 268-278 p.
Keyword [en]
interaction effects, memory, APOE, lipids, longitudinal
National Category
Psychology
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-34540DOI: 10.1027/1016-9040.14.4.268ISI: 000272840300002OAI: oai:DiVA.org:su-34540DiVA: diva2:285026
Projects
Betulaprojektet
Note
The Betula Longitudinal Project is supported by the Bank of Sweden Tercentenary Foundation (1988–0082:17), Swedish Council for Planning and Coordination of Research (D1988-0092, D1989-0115, D1990- 0074, D1991-0258, D1992-0143, D1997-0756, D1997- 1841, D1999-0739, and B1999-474), Swedish Council for Research in the Humanities and Social Sciences (F377/1988-2000), and the Swedish Council for Social Research (1988–1990: 88-0082, and 311/1991–2000). Ola Sternäng was supported by grants from Helge Ax:son Johnson Foundation and from Elisabeth and Herman Rhodin’s Foundation. Åke Wahlin was funded by a grant from Swedish Council for Research in the Humanities and Social Sciences (Dnr 421-2007-1616). Genotyping was supported in part by the Interuniversity Attraction Poles Program (IAP P6/43) of the Belgian Science Policy Office, the Fund for Scientific Research –Flanders (FWOF), and the Stichting voor Alzheimer Onderzoek, Belgium.Available from: 2010-01-10 Created: 2010-01-10 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Individual differences in the aging memory: Mediation accounts, moderators, and contextual factors
Open this publication in new window or tab >>Individual differences in the aging memory: Mediation accounts, moderators, and contextual factors
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Within the field of cognitive aging, mediation accounts propose that age affects cognitive abilities through a mediator variable. Most of these mediation accounts are developed based on studies with cross-sectional designs. We had access to data from Betula, a longitudinal population-based multi-cohort project, and tested, in Study I, the well-known processing speed account (general age-related slowing of mental processing speed affects cognitive abilities negatively) (Salthouse, 1996). Interestingly, no support was found for the speed account. In Study II, a second mediation theory was tested, the common cause account (Lindenberger & Baltes, 1994). This notion suggests a link between sensory and cognitive abilities, where both abilities decline with age in a similar fashion because of a third factor, a common cause. Again, no support for a major account of cognitive decline was found. In Study III, interactions including vascular health and genetic status (APOE status) as potential interacting predictors of cognitive development were examined. A difference in the distribution of interaction effects on episodic and semantic memory development was found. Study IV, finally, consisted of a comparison of cognitive aging in two very different countries, Bangladesh (Poverty and Health in Ageing) and Sweden (Betula). The findings were surprising since chronological age, in Bangladesh, did not exert much effect on declarative memory in older people, in contrast to Betula and most other aging studies, predominantly performed in the Western world. Results from these four studies are discussed with respect to theoretical implications and methodological considerations. Recommendations for future research focus are made and implications for explanatory models of cognitive aging are elaborated on.

 

Place, publisher, year, edition, pages
Stockholm: Department of Psychology, Stockholm University, 2010. 73 p.
Keyword
cognitive aging, interactions, context, mediation accounts, cross-cultural, longitudinal, individual differences
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-45917 (URN)978-91-7447-158-8 (ISBN)
Public defence
2011-01-14, David Magnusson salen (U31), Frescati Hagväg 8, Stockholm, 14:00 (English)
Opponent
Supervisors
Note
At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 4: Manuscript.Available from: 2010-12-22 Created: 2010-11-16 Last updated: 2010-12-01Bibliographically approved

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