TOPCONS: consensus prediction of membrane protein topology
2009 (English)In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 37, no Suppl. 2, W465-W468 p.Article in journal (Refereed) Published
TOPCONS (http://topcons.net/) is a web server for consensus prediction of membrane protein topology. The underlying algorithm combines an arbitrary number of topology predictions into one consensus prediction and quantifies the reliability of the prediction based on the level of agreement between the underlying methods, both on the protein level and on the level of individual TM regions. Benchmarking the method shows that overall performance levels match the best available topology prediction methods, and for sequences with high reliability scores, performance is increased by approximately 10 percentage points. The web interface allows for constraining parts of the sequence to a known inside/outside location, and detailed results are displayed both graphically and in text format.
Place, publisher, year, edition, pages
2009. Vol. 37, no Suppl. 2, W465-W468 p.
Biochemistry and Molecular Biology
Research subject Biochemistry with Emphasis on Theoretical Chemistry
IdentifiersURN: urn:nbn:se:su:diva-34577DOI: 10.1093/nar/gkp363ISI: 000267889100081PubMedID: 19429891OAI: oai:DiVA.org:su-34577DiVA: diva2:285154
FunderEU, FP7, Seventh Framework Programme, 512092; 201924Swedish Research CouncilSwedish Foundation for Strategic Research