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Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations
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2009 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 46, no 4, 1194-1199 p.Article in journal (Refereed) Published
Abstract [en]

Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.

Place, publisher, year, edition, pages
Elsevier , 2009. Vol. 46, no 4, 1194-1199 p.
Keyword [en]
multi-modal brain imaging, memory, striatal dopamine D2 binding, BOLD
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Research subject
URN: urn:nbn:se:su:diva-34908DOI: 10.1016/j.neuroimage.2009.03.035ISI: 000266975600033PubMedID: 19327403ScopusID: 2-s2.0-67349197089OAI: diva2:285942

We thank Lena Öhman and Cindy de Frias for assisting in data collection. This research was supported by grants from the Swedish Research Council to LN, LGN, and LB from the Swedish Brain Power to LB, and from NOS-HS for a Nordic Centre of Excellence in Cognitive Control to LN.

Available from: 2010-01-13 Created: 2010-01-13 Last updated: 2015-09-01Bibliographically approved

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Nilsson, Lars-Göran
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Department of Psychology
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