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RNA editing and its impact on GABAa receptor function
Stockholm University, Faculty of Science, Department of Molecular Biology and Functional Genomics.
Stockholm University, Faculty of Science, Department of Molecular Biology and Functional Genomics.
2009 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 37, 1399-1403 p.Article in journal (Refereed) Published
Abstract [en]

A-to-I (adenosine-to-inosine) RNA editing catalysed by the ADARs (adenosine deaminases that act on RNA) is a post-transcriptional event that contributes to protein diversity in metazoans. In mammalian neuronal ion channels, editing alters functionally important amino acids and creates receptor subtypes important for the development of the nervous system. The excitatory AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) and kainate glutamate receptors, as well as the inhibitory GABAA [GABA (γ-aminobutyric acid) type A] receptor, are subject to A-to-I RNA editing. Editing affects several features of the receptors, including kinetics, subunit assembly and cell-surface expression. Here, we discuss the regulation of editing during brain maturation and the impact of RNA editing on the expression of different receptor subtypes.

Place, publisher, year, edition, pages
Biochemical Society , 2009. Vol. 37, 1399-1403 p.
Keyword [en]
adenosine deaminase that acts on RNA (ADAR), central nervous system (CNS), endoplasmic reticulum, γ-aminobutyric acid type A receptor (GABAA receptor), RNA editing, transmembrane region.
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-35077DOI: 10.1042/BST0371399ISI: 000272646000047OAI: oai:DiVA.org:su-35077DiVA: diva2:286323
Available from: 2010-01-14 Created: 2010-01-14 Last updated: 2017-12-12Bibliographically approved

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