Parallel synthesis of an indole-based library via an iterativeMannich reaction sequence
2006 (English)In: Tetrahedron, ISSN 0040-4020, Vol. 62, no 14, 3439-3445 p.Article in journal (Refereed) Published
A library of 1,3-disubstituted indoles has been prepared via an iterative Mannich reaction sequence. The first Mannich reaction with secondary amines and formaldehyde preferentially yields 3-aminomethyl indoles, while the second Mannich reaction introduces an additional aminomethyl group at the N1-position of the indole ring. A library of 25 substituted indoles has thus been prepared in moderate to good yields with purity.
Place, publisher, year, edition, pages
Elsevier Ltd. , 2006. Vol. 62, no 14, 3439-3445 p.
Library synthesis, Mannich reaction, Affinity ligands
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-35081DOI: 10.1016/j.tet.2006.01.047OAI: oai:DiVA.org:su-35081DiVA: diva2:286550