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Plasticity and recovery of skeletal muscle satellite cells during limb regeneration
Stockholm University, Faculty of Science, Department of Molecular Biology and Functional Genomics.
2010 (English)In: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 24, no 3, 750-756 p.Article in journal (Refereed) Published
Abstract [en]

Salamander limb regeneration depends on local progenitors whose progeny are recruited to the new limb. We previously identified a Pax7+ cell population in skeletal muscle whose progeny have the potential to contribute to the regenerating limb. However, the plasticity of individual Pax7+ cells, as well as their recovery within the new limb, was unclear. Here, we show that Pax7+ cells remain present after multiple rounds of limb amputation/regeneration. Pax7+ cells are found exclusively within skeletal muscle in the regenerating limb and proliferate where the myofibers are growing. Pax7 is rapidly down-regulated in the blastema, and analyses of clonal derivatives show that Pax7+ cell progeny are not restricted to skeletal muscle during limb regeneration. Our data suggest that the newt regeneration blastema is not entirely a composite of lineage-restricted progenitors. The results demonstrate that except for a transient and subsequently blunted increase, skeletal muscle satellite cells constitute a stable pool of reserve cells for multiple limb regeneration events.

Place, publisher, year, edition, pages
FASEB , 2010. Vol. 24, no 3, 750-756 p.
Keyword [en]
Pax7, blastema, salamander, reprogramming
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-35376DOI: 10.1096/fj.09-134825OAI: oai:DiVA.org:su-35376DiVA: diva2:287194
Available from: 2010-01-18 Created: 2010-01-18 Last updated: 2017-12-12Bibliographically approved

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