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Antibacterial activity of radical scavengers against reductase from Bacillus anthracis
Stockholm University, Faculty of Science, Department of Molecular Biology and Functional Genomics.
2010 (English)In: Biological chemistry (Print), ISSN 1431-6730, E-ISSN 1437-4315, Vol. 391, no 2/3, 229-234 p.Article in journal (Refereed) Published
Abstract [en]

Bacillus anthracis is a severe mammalian pathogen. The deoxyribonucleotides necessary for DNA replication and repair are provided via the ribonucleotide reductase (RNR) enzyme. RNR is also important for spore germination and cell proliferation upon infection. We show that the expression of B. anthracis class Ib RNR responds to the environment that the pathogen encounters upon infection. We also show that several anti-proliferative agents (radical scavengers) specifically inhibit the B. anthracis RNR. Owing to the importance of RNR in the pathogenic infection process, our results highlight a promising potential to inhibit the growth of B. anthracis early during infection.

Place, publisher, year, edition, pages
2010. Vol. 391, no 2/3, 229-234 p.
Keyword [en]
anthrax, antibacterial drug, antibacterial target, enzyme inhibition
National Category
Natural Sciences
URN: urn:nbn:se:su:diva-35408DOI: 10.1515/BC.2010.017OAI: diva2:287231
Available from: 2010-01-18 Created: 2010-01-18 Last updated: 2010-12-17Bibliographically approved

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Sjöberg, Britt-Marie
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