Mesostructured silica based delivery system for a drug with a peptide as a cell-penetrating vector
2009 (English)In: Microporous and Mesoporous Materials, ISSN 1387-1811, Vol. 122, no 1-3, 201-207 p.Article in journal (Refereed) Published
A drug delivery system using mesostructured silica as a reservoir has been developed for the storage and controlled release of a drug with a cell-penetrating peptide (CPP) as a vector. We use fluorescein isothiocyanate (FITC) as the drug model and octaarginine (R8) as a vector to endow the drug with cell-penetrating property. The mesostructured silica reservoir system was prepared by using a one-pot liquid?crystal templating method, which is suitable for the encapsulation of intact FITC-R8 conjugates and sustained release of drugs without hampering their properties. The hydrophobic poly(propyl oxide) (PPO) shell of the pore-filling Pluronic F127 and the electrostatic interaction between R8 and siloxide ions on the pore walls act as the diffusion-limiting factors of the FITC-R8 conjugate. A sigmoidal in vitro release of FITC-R8 from mesostructured silica into phosphate buffered saline (PBS, pH 7.4) was observed and the typical release duration was 5 days at 37 ‹C. Release from the reservoir yielded significant elongation in duration of the FITC signals in DU145 cells by confocal microscopic analysis, compared with a single administration of FITC-R8.
Place, publisher, year, edition, pages
2009. Vol. 122, no 1-3, 201-207 p.
Mesostructured silica, Drug delivery, Cell-penetrating peptide, Sigmoidal release, Sustained cellular uptake
Research subject Structural Chemistry
IdentifiersURN: urn:nbn:se:su:diva-36704DOI: 10.1016/j.micromeso.2009.03.002ISI: 000266061500029OAI: oai:DiVA.org:su-36704DiVA: diva2:289969
övrigt antal författare 7st.2010-01-252010-01-252011-04-12Bibliographically approved