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Multidetection and chemometrics in flow injection analysis
Stockholm University, Faculty of Science, Department of Analytical Chemistry.
1997 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

An ideal method for the determination of ions in aqueous solutions should be fast, inexpensive, simple, reliable and require small sample volumes. Flow Injection Analysis (FIA) is in many respects such an ideal method but it is too often limited to the determination of one analyte at a time. In this thesis some system design aspects have been addressed. A new system for multianalyte determination has been developed which is based on the hyphenation of FIA with capillary electrophoresis (CE). Chemometrics have been used to optimise the design of this new system and further to optimise the design of a typical single analyte FIA manifold namely a gas diffusion manifold for the determination of ammonia.

The second major theme in this work is the development of new signal evaluation methods for FIA and FIA-CE systems. By using a multivariate approach the simultaneous determination of ammonium and excess acid (sulphuric acid) in one single run has been made possible. For conventional two line or gas diffusion applications in FIA, peak area by triangulation was found to be the evaluation method of choice both for "normal" and extended analyte concentration ranges. For the FIA-CE system, which is based on electrokinetic injection, various evaluation methods, both univariate and multivariate, were critically examined and compared. The conductivity corrected peak area method is superior to the traditionally used evaluation principles such as peak height, peak area, standard addition and internal standard methods.

Place, publisher, year, edition, pages
Stockholm: Department of Analytical Chemistry, Stockholm University , 1997. , 68 p.
National Category
Other Basic Medicine
Research subject
Analytical Chemistry
URN: urn:nbn:se:su:diva-37010ISBN: 91-7153-699-XOAI: diva2:291803
Public defence
1998-01-23, Magnélisalen, KÖL, Frescati, Stockholm, 10:00 (English)
Härtill 5 uppsatser Available from: 2010-02-03 Created: 2010-02-03 Last updated: 2010-11-09Bibliographically approved

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