Preparation of benzylphosphonates via a palladium(0)-catalyzed cross-coupling of H-phosphonate diesters with benzyl halides. Synthetic and mechanistic studies
2010 (English)In: New Journal of Chemistry, ISSN 1144-0546, E-ISSN 1369-9261, Vol. 34, no 5, 967-975 p.Article in journal (Refereed) Published
We have developed a new, efficient method for the synthesis of benzylphosphonate andbenzylphosphonothioate diesters via a palladium(0)-catalyzed cross-coupling reaction betweenbenzyl halides and H-phosphonate or H-phosphonothioate diesters, using Pd2(dba)3(CHCl3)as a palladium source and Xantphos as a supporting ligand. Some mechanistic aspects of thesereactions were investigated using 31P NMR spectroscopy.
Place, publisher, year, edition, pages
Royal Society of Chemistry, 2010. Vol. 34, no 5, 967-975 p.
IdentifiersURN: urn:nbn:se:su:diva-38775DOI: 10.1039/b9nj00585dISI: 000277399200022OAI: oai:DiVA.org:su-38775DiVA: diva2:315045
FunderSwedish Research Council