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Familial factors confound the associationbetween maternal smoking during pregnancyand young adult offspring overweight
Stockholm University, Faculty of Social Sciences, Centre for Health Equity Studies (CHESS).
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2010 (English)In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 39, no 5, 1193-1202 p.Article in journal (Refereed) Published
Abstract [en]

Background Smoking during pregnancy has been shown to increase the risks of several adverse birth outcomes. Associations with overweight and/or obesity in the offspring have also been suggested. We aim to investigate whether familial factors confound the association between maternal smoking during pregnancy and overweight in early adulthood in young Swedish males born 1983–88.

Methods In a population-based Swedish cohort comprising 124 203 singleton males born to Nordic mothers between 1983 and 1988, we examined the association between maternal smoking during pregnancy and the risk of overweight in the offspring at age ∼18 years. We also investigated the association within siblings, controlling for common genes and shared environment.

Results In the cohort analyses, the risk of overweight was increased in sons of smoking mothers compared with sons of non-smokers: adjusted odds ratios 1.41, 95% confidence interval (CI) 1.34–1.49, and 1.56, 95% CI 1.46–1.66, for one to nine cigarettes per day, and >10 cigarettes per day, respectively. Stratifying for maternal smoking habits across two subsequent male pregnancies, there was an increased risk of overweight for the second son only if the mother was smoking in both male pregnancies. The effect of smoking during pregnancy on the offspring’s body mass index was not present when the association was evaluated within full and half sibling pairs.

Conclusion The association between maternal smoking during pregnancy and offspring’s risk of overweight appears to be confounded by familial factors.

Place, publisher, year, edition, pages
2010. Vol. 39, no 5, 1193-1202 p.
National Category
Social Sciences
URN: urn:nbn:se:su:diva-40236DOI: 10.1093/ije/dyq064ISI: 000283932000013OAI: diva2:323027
Available from: 2010-06-09 Created: 2010-06-09 Last updated: 2011-11-21Bibliographically approved

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Koupil, Ilona
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