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Distribution of a novel cardioactive neuropeptide (CCAP) in the nervous system of the shore crab Carcinus maenas.
Institute of Zoophysiology, University of Bonn, Germany.ORCID iD: 0000-0001-7815-4868
1988 (English)In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 9, no 4, 795-800 p.Article in journal (Refereed) Published
Abstract [en]

A radioimmunoassay (RIA) for the recently discovered crustacean cardioactive peptide (CCAP) has been developed and used to determine contents of CCAP in different parts of the nervous system of the shore crab Carcinus maenas. Immunoreactive material was detected throughout the nervous system. In contrast to the main ganglia which contained low levels of approximately 1.4 pmol CCAP/mg protein (brain and thoracic ganglion), a high concentration was found in a neurohemal structure, the pericardial organs (PO) (868 pmol/mg protein). A predominantly neurohormonal role of CCAP thus suggested is further supported by in vitro release studies. Incubation of POs in high (K+) saline showed that CCAP is secretable in considerable amounts by a Ca++-dependent release mechanism.

Place, publisher, year, edition, pages
Elsevier , 1988. Vol. 9, no 4, 795-800 p.
National Category
Biological Sciences
URN: urn:nbn:se:su:diva-40043DOI: 10.1016/0196-9781(88)90124-6PubMedID: 3226956OAI: diva2:326357
Available from: 2010-06-22 Created: 2010-06-04 Last updated: 2014-10-13Bibliographically approved

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