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Early cognitive impairment in a subset of patients with presumed low-grade glioma 
Stockholm University, Faculty of Social Sciences, Department of Psychology.
Stockholm University, Faculty of Social Sciences, Department of Psychology.
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2010 (English)In: Neurocase, ISSN 1355-4794, E-ISSN 1465-3656, Vol. 16, no 6, 503-511 p.Article in journal (Refereed) Published
Abstract [en]

We investigated the presence of cognitive impairment, in adults with presumed low-grade glioma at early stage of disease prior to major treatments, in relation to neurological symptoms and radiological characteristics of the tumour. Sixteen patients were evaluated. A subset of patients was identified with clearly impaired cognition. Patients with cognitive impairment often had large tumours in the left frontal lobe, were relatively young, and most of them were males. We conclude that cognitive dysfunction may be present already at early stage of disease, and that early identification of patients at risk is warranted.

Place, publisher, year, edition, pages
2010. Vol. 16, no 6, 503-511 p.
Keyword [en]
Low-grade glioma, Brain tumour, Cognition, Depression, MRI
National Category
Psychology
Identifiers
URN: urn:nbn:se:su:diva-41304DOI: 10.1080/13554791003730634ISI: 000284629400005OAI: oai:DiVA.org:su-41304DiVA: diva2:329403
Note
First Published on: 02 June 2010 on Neurocase websiteAvailable from: 2010-07-10 Created: 2010-07-10 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Cognitive Deficits Reflecting Diffuse and Focal Brain Lesions Caused by Slow Growing Brain Tumors - Low-grade Gliomas
Open this publication in new window or tab >>Cognitive Deficits Reflecting Diffuse and Focal Brain Lesions Caused by Slow Growing Brain Tumors - Low-grade Gliomas
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Alternative title[sv]
Tankemässiga nedsättningar speglar diffus och fokal hjärnskada orsakad av långsamt växande hjärntumör - lågmalignt gliom
Abstract [en]

The overall purpose was to characterize the impact that low-grade glioma (LGG) – a type of slowly growing brain tumor – has on cognitive functions.

Paper I was an in-depth analysis of cognitive dysfunction of patients with histological proven LGG. The pattern varied among patients, revealing three subgroups: 1) patients with severe cognitive dysfunction; 2) patients with mild cognitive dysfunction; 3) patients with selective dysfunction due to tumor localization. In the first two subgroups the patients had slowed information-processing speed. Patients with a favorable prognosis performed better than those with unfavorable prognosis. Nonworking patients showed more pronounced dysfunction than working patients.

Paper II studied cognitive functions of patients who were in the early stage of the disease and had not yet received any major medical treatments. Patients’ performances ranked at the lower end of normal limits, which contrasted with those of the individually matched controls, whose performances ranked at the upper end. Patients had slower information-processing-speed and less effective executive functions. Patients with frontal tumors had various executive problems due to tumor localization. Paper III investigated cognitive impairment at the individual level in relation to neurological symptoms, radiological characteristics of the tumor, depression, and fatigue.

 Paper III included the same patients as Paper II. The results showed that the majority of the patients did not have more than selective impairment. One subgroup, consisting of younger patients with large left frontal tumors showed obvious cognitive impairment, including slowed information-processing speed.

The thesis showed that diffuse brain injury was closely connected to LGG. A subgroup of patients in the early phase of the disease showed signs of mild diffuse brain injury. The majority of the patients who were in later stage of the disease displayed cognitive signs of diffuse brain injury.

Place, publisher, year, edition, pages
Stockholm: Department of Psychology, Stockholm University, 2010. 77 p.
Keyword
Cognition, low-grade glioma, brain tumor, diffuse brain injury, neuropsychological tests
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-41305 (URN)978-91-7447-127-4 (ISBN)
Public defence
2010-12-10, David Magnussonsalen, hus 8, Frescati hagväg 8, Stockholm, 10:00 (Swedish)
Opponent
Supervisors
Note
At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 2: Manuscript.Available from: 2010-11-17 Created: 2010-07-10 Last updated: 2010-11-08Bibliographically approved

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