Change search
ReferencesLink to record
Permanent link

Direct link
Fetal and life course origins of serum lipids in mid-adulthood: results from a prospective cohort study
Stockholm University, Faculty of Social Sciences, Stress Research Institute.
Stockholm University, Faculty of Social Sciences, Stress Research Institute.
Show others and affiliations
2010 (English)In: BMC Public Health, ISSN 1471-2458, Vol. 10, no 1, 484- p.Article in journal (Refereed) Published
Abstract [en]

ABSTRACT: BACKGROUND: During the past two decades, the hypothesis of fetal origins of adult disease has received considerable attention. However, critique has also been raised regarding the failure to take the explanatory role of accumulation of other exposures into consideration, despite the wealth of evidence that social circumstances during the life course impact on health in adulthood. The aim of the present prospective cohort study was to examine the contributions of birth weight and life course exposures (cumulative socioeconomic disadvantage and adversity) to dyslipidemia and serum lipids in mid-adulthood. METHODS: A cohort (effective n = 824, 77%) was prospectively examined with respect to self-reported socioeconomic status as well as stressors (e.g., financial strain, low decision latitude, separation, death or illness of a close one, unemployment) at the ages of 16, 21, 30 and 43 years; summarized in cumulative socioeconomic disadvantage and cumulative adversity. Information on birth weight was collected from birth records. Participants were assessed for serum lipids (total cholesterol, low- and high-density lipoprotein cholesterol and triglycerides), apolipoproteins (A1 and B) and height and weight (for the calculation of body mass index, BMI) at age 43. Current health behavior (alcohol consumption, smoking and snuff use) was reported at age 43. RESULTS: Cumulative life course exposures were related to several outcomes; mainly explained by cumulative socioeconomic disadvantage in the total sample (independently of current health behaviors but attenuated by current BMI) and also by cumulative adversity in women (partly explained by current health behavior but not by BMI). Birth weight was related only to triglycerides in women, independently of life course exposures, health behaviors and BMI. No significant association of either exposure was observed in men. CONCLUSIONS: Social circumstances during the life course seem to be of greater importance than birth weight for dyslipidemia and serum lipid levels in adulthood.

Place, publisher, year, edition, pages
2010. Vol. 10, no 1, 484- p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:su:diva-42154DOI: 10.1186/1471-2458-10-484ISI: 000282237100002PubMedID: 20712860Local ID: P2813OAI: diva2:344193
Available from: 2010-08-18 Created: 2010-08-18 Last updated: 2011-11-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Theorell, ToresWesterlund, Hugo
By organisation
Stress Research Institute
In the same journal
BMC Public Health
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 24 hits
ReferencesLink to record
Permanent link

Direct link