Modeling bioaccumulation in humans using poly-parameter linear free energy relationships (ppLFERs)
2011 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 409, no 9, 1726-1731 p.Article in journal (Refereed) Published
Chemical partition coefficients between environmental media and biological tissues are a key component of bioaccumulation models. The single-parameter linear free energy relationships (spLFERs) commonly used for predicting partitioning are often derived using apolar chemicals and may not accurately capture polar chemicals. In this study, a poly-parameter LFER (ppLFER) based model of organic chemical bioaccumulation in humans is presented. Chemical partitioning was described by an air–body partition coefficient that was a volume weighted average of ppLFER based partition coefficients for the major organs and tissues constituting the human body. This model was compared to a spLFER model treating the body as a mixture of lipid(≈octanol) and water. Although model agreement was good for hydrophobic chemicals (average difference 15% for log KOWN4 and log KOAN 8), the ppLFER model predicted ~90% lower body burdens for hydrophilic chemicals (log KOWb0). This was mainly due to lower predictions of muscle and adipose tissue sorption capacity for these chemicals. A comparison of the predicted muscle and adipose tissue sorption capacities of hydrophilic chemicals with measurements indicated that the ppLFER and spLFER models' uncertainties were similar. Consequently, little benefit from the implementation of ppLFERs in this model was identified. hydrophilic chemicals with measurements indicated that the ppLFER and spLFER models' uncertainties were similar. Consequently, little benefit from the implementation of ppLFERs in this model was identified.
Place, publisher, year, edition, pages
2011. Vol. 409, no 9, 1726-1731 p.
ppLFER, Human bioaccumulation, Partition coefficients
Research subject Applied Environmental Science
IdentifiersURN: urn:nbn:se:su:diva-42345DOI: 10.1016/j.scitotenv.2011.01.044ISI: 000288738900015OAI: oai:DiVA.org:su-42345DiVA: diva2:345458