Design and asymmetric synthesis of chiral diaryliodonium salts
2010 (English)In: Tetrahedron, ISSN 0040-4020, E-ISSN 1464-5416, Vol. 66, no 31, 5793-5800 p.Article in journal (Refereed) Published
The application of chiral hypervalent iodine reagents in asymmetric synthesis is highly desirable, as the reagents are metal-free, environmentally benign and employed under mild conditions. Three chiral diaryliodonium salts have been designed to provide chemoselectivity and asymmetric induction in asymmetric alpha-phenylation of carbonyl compounds. The synthetic routes to the selected targets are detailed herein, together with a structural investigation into the diastereoselectivity of the alkylation process.
Place, publisher, year, edition, pages
2010. Vol. 66, no 31, 5793-5800 p.
Hypervalent iodine, Diaryl-[lambda]3-iodanes, Asymmetric synthesis, Oxidation, Arylation reagents
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-43501DOI: 10.1016/j.tet.2010.05.004ISI: 000280344200009OAI: oai:DiVA.org:su-43501DiVA: diva2:357353
FunderSwedish Research Council, 621-2008-3709