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The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice
Stockholm University, Faculty of Science, The Wenner-Gren Institute .
Stockholm University, Faculty of Science, The Wenner-Gren Institute .
2010 (English)In: Progress in lipid research, ISSN 0163-7827, E-ISSN 1873-2194, Vol. 49, no 2, 186-99 p.Article in journal (Refereed) Published
Abstract [en]

In mammalian cells, elongases and desaturases play critical roles in regulating the length and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In the past decade, a great deal has been learnt about these enzymes and the first part of this review summarizes our current knowledge concerning these enzymes. More recently, several transgenic mouse models lacking either an elongase (Elovl3(-/-), Elovl4(-/-), Elovl5(-/-), Elovl6(-/-)) or a desaturase (Scd-1(-/-), Scd-2(-/-), Fads2(-/-)) have been developed and the second part of this review focuses on the insights gained from studies with these mice, as well as from investigations on cell cultures.

Place, publisher, year, edition, pages
2010. Vol. 49, no 2, 186-99 p.
National Category
Natural Sciences
URN: urn:nbn:se:su:diva-44309DOI: 10.1016/j.plipres.2009.12.002PubMedID: 20018209OAI: diva2:360946
Available from: 2010-11-05 Created: 2010-11-05 Last updated: 2010-12-30Bibliographically approved

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