Change search
ReferencesLink to record
Permanent link

Direct link
Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
Show others and affiliations
2010 (English)In: Molecular medicine (Cambridge, Mass. Print), ISSN 1076-1551, Vol. 16, no 1-2, 27-33 p.Article in journal (Refereed) Published
Abstract [en]

The role of inflammation in malaria pathogenesis is not fully understood, although C-reactive protein (CRP) may have a negative influence on host immunity to infections. An upstream polymorphism, -286 (C > T > A), in the CRP gene is known to influence CRP levels. In this study, a cohort of 192 Sudanese donors, followed for malaria infection for 9 years, had their CRP -286 gene locus genotyped by pyrosequencing. The number of malaria episodes experienced by each individual over the study period was used as an index for malaria susceptibility. The prevalence of the CRP alleles A, C and T were 21%, 52% and 27%, respectively. Importantly, the A-allele, unlike the C- and T-alleles or CRP genotypes, was significantly associated with an increased number of malaria episodes, P = 0.007. The proportion of A-allele carriers among donors not known to have had malaria during the study period was 18%, whereas it was 43% and 63% among donors who had experienced 1-4 and > or =5 malaria episodes, respectively, over the same period (P = 0.002). Furthermore, the A-allele was associated with higher parasite counts. In conclusion, the CRP -286 A-allele was associated with an increased susceptibility to uncomplicated Plasmodium falciparum malaria.

Place, publisher, year, edition, pages
2010. Vol. 16, no 1-2, 27-33 p.
National Category
Natural Sciences
URN: urn:nbn:se:su:diva-45669DOI: 10.2119/molmed.2009.00136ISI: 000276044100004PubMedID: 19946607OAI: diva2:369288
authorCount>11Available from: 2010-11-10 Created: 2010-11-10 Last updated: 2010-12-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Nasr, AmreTroye-Blomberg, MaritaBerzins, Klavs
By organisation
In the same journal
Molecular medicine (Cambridge, Mass. Print)
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 93 hits
ReferencesLink to record
Permanent link

Direct link