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Clustering of malaria treatment failure (TF) in Daraweesh: hints for host genetic susceptibility to TF with emphasis on immune-modulating SNPs
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
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2010 (English)In: Infection, Genetics and Evolution, ISSN 1567-1348, E-ISSN 1567-7257, Vol. 10, no 4, 481-6 p.Article in journal (Refereed) Published
Abstract [en]

In malaria, drug resistance and treatment failure (TF) are not synonymous, although are escalating together. Over 9 years of surveillances for malaria morbidity and TF in Daraweesh village in eastern Sudan (1991-2004), 136 donors (15-78 years) from 43 households, treated for 278 malaria episodes and had experienced 46 incident of TF, were included in this study. Blood obtained from the donors in 2005, was used for measurement of IgG subclasses against Pf332-C231 antigen and GM/KM allotyping and for genotyping of the donors for; FcgammaRIIA 131 (HH, RH, RR), CRP 286 (C

Place, publisher, year, edition, pages
2010. Vol. 10, no 4, 481-6 p.
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Natural Sciences
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URN: urn:nbn:se:su:diva-45671DOI: 10.1016/j.meegid.2010.02.013ISI: 000278629900008PubMedID: 20215002OAI: oai:DiVA.org:su-45671DiVA: diva2:369297
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authorCount :8Available from: 2010-11-10 Created: 2010-11-10 Last updated: 2017-12-12Bibliographically approved

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