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Application of Geant4 in the development of new radiation therapy treatment methods
Karolinska Institutet, Medical Radiation Physics.
Stockholm University, Faculty of Science, Department of Physics.
Karolinska Institutet, Medical Radiation Physics.
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2006 (English)In: Proceedings of the 9th Conference, Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications / [ed] Michele Barone, Emilio Borchi, Andrea Gaddi, claude Leroy, Larry Price, Pier-Giorgio Rancoita, Randal Ruchti, 5 Toh Tuck Link, singapore: World Scientific Publishing Co. Pte. Ltd. , 2006, 451-461 p.Conference paper, Published paper (Refereed)
Abstract [en]

There is a very fast development of new radiation treatment methods today, from advanced use of intensity modulated photon and electron beams to light ion therapy with narrow scanned beam based treatment units. Accurate radiation transport calculations are a key requisite for these developments where Geant4 is a very useful Monte Carlo code for accurate design of new treatment units. Today we cannot only image the tumor by PET-CT imaging before the treatment but also determine the tumor sensitivity to radiation and even measure in vivo the delivered absorbed dose in three dimensions in the patient. With such methods accurate Monte Carlo calculations will make radiation therapy an almost exact science where the curative doses can be calculated based on patient individual response data. In the present study results from the application of Geant4 are discussed and the comparisons between Geant4 and experimental and other Monte Carlo data are presented.

Place, publisher, year, edition, pages
5 Toh Tuck Link, singapore: World Scientific Publishing Co. Pte. Ltd. , 2006. 451-461 p.
National Category
Natural Sciences
Research subject
Medical Radiation Physics
Identifiers
URN: urn:nbn:se:su:diva-45776ISBN: 981-256-798-4 (print)OAI: oai:DiVA.org:su-45776DiVA: diva2:369774
Conference
Astroparticle, Particle and Space Physics, detector and Medical Physics Applications
Available from: 2010-11-11 Created: 2010-11-11 Last updated: 2012-01-12Bibliographically approved
In thesis
1. Development of improved radiation therapy techniques using narrow scanned photon beams
Open this publication in new window or tab >>Development of improved radiation therapy techniques using narrow scanned photon beams
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The present thesis is focused on the development and application of narrow scanned high energy photon beam for radiation therapy. The introduction of physically and biologically optimized intensity modulated radiation therapy (IMRT) requires a flexible and accurate dose delivery method to maximize the treatment outcome. Narrow scanned photon beams is a fast option for IMRT since it is not dependent on mechanically moving heavy collimator leafs and largely independent of the complexity of the desired dose distribution. Scanned photon beams can be produced by scanning an electron beam of low emittance, incident on a thin bremsstrahlung target of low atomic number. The large fraction of high energy electrons that are transmitted through the target has to be removed by a strong purging magnet. In the thesis a strong purging magnet, coupled with a magnetic scanning magnet, is presented for an intrinsic electron energy of 50 - 75 MeV and a source to isocenter distance of 75 cm. The available scan area at isocenter can be as large as 43 x 40 cm2 for an incident electron energy of 50 MeV and 28 x 40 cm2 at 75 MeV.

By modifying the existing treatment head of the racetrack microtron MM50, it was possible to experimentally produce relevant dose distributions with interesting properties from 50 MV scanned narrow photon beams while deflecting the transmitted electrons onto a simplified electron stopper. The deflection of the transmitted electrons was studied both experimentally and by the Monte Carlo method. With high energy photons, treatment verification is possible through PET-CT imaging of the positron annihilations induced by photonuclear reactions in the patient. Narrow scanned high energy photon beams is the ideal beam quality since the activation efficiency and the effective photon energy will be more uniform than the filtered photon beam from a full range bremsstrahlung target.

The induced 11C activity 50 MV by scanned narrow photon beams was measured using PET-CT imaging and compared with Monte Carlo simulations. The combination of fast flexible dose delivery with treatment verification using PET-CT imaging makes narrow high energy scanned photon beams a very interesting treatment modality for biologically optimized adaptive radiation therapy.

Place, publisher, year, edition, pages
Stockholm: Department of Physics, Stockholm University, 2010. 36 p.
Keyword
IMRT, Scanned photon beams, PET-CT treatment verification, Monte Carlo
National Category
Natural Sciences
Research subject
Medical Radiation Physics
Identifiers
urn:nbn:se:su:diva-45809 (URN)978-91-7447-189-2 (ISBN)
Public defence
2010-12-10, Föreläsningssalen, Cancer Centrum Karolinska, R8:00, Karolinska universitetssjukhuset, Solna, 14:00 (English)
Opponent
Supervisors
Note
At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Submitted. Paper 4: Submitted.Available from: 2012-01-12 Created: 2010-11-11 Last updated: 2012-01-12Bibliographically approved

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