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Synthesis of inositol phosphoglycans and analogues thereof
Stockholm University, Faculty of Science, Department of Organic Chemistry.
1998 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis describes the synthesis of inositol phosphoglycans (IPG) corresponding to glycosyl-phosphatidylinositol (GPI) anchors found on the cell surface of the parasite Leishmania. Synthesis of an IPG which is a putative second messenger for insulin, and of analogues thereof is also discussed.

The IPG structures synthesized contain mono-, tri-, and hexasaccharides linked to an inositol phosphate. Analogues of the putative second messenger contain glucosamine, instead of myo-inositol phosphate, coupled to either phosphorylated D-mannose or phosphorylated L-fucose. The synthetic work involved the development of procedures for obtaining optically pure myo-inositol-glucosamine derivatives, the formation of phosphomono- and diesters (both cyclic and acyclic) and oligosaccharide synthesis.

Place, publisher, year, edition, pages
Stockholm: Stockholms universitet , 1998. , 40 p.
National Category
Organic Chemistry
Research subject
Organic Chemistry
URN: urn:nbn:se:su:diva-45912ISBN: 91-7153-741-4OAI: diva2:370337
Public defence
1998-06-04, Magnélisalen, KÖL, Frescati, Stockholm, 10:00 (English)
Härtill fyra uppsatser.Available from: 2010-11-16 Created: 2010-11-16 Last updated: 2010-11-16Bibliographically approved

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