Synthesis of inositol phosphoglycans and analogues thereof
1998 (English)Doctoral thesis, comprehensive summary (Other academic)
This thesis describes the synthesis of inositol phosphoglycans (IPG) corresponding to glycosyl-phosphatidylinositol (GPI) anchors found on the cell surface of the parasite Leishmania. Synthesis of an IPG which is a putative second messenger for insulin, and of analogues thereof is also discussed.
The IPG structures synthesized contain mono-, tri-, and hexasaccharides linked to an inositol phosphate. Analogues of the putative second messenger contain glucosamine, instead of myo-inositol phosphate, coupled to either phosphorylated D-mannose or phosphorylated L-fucose. The synthetic work involved the development of procedures for obtaining optically pure myo-inositol-glucosamine derivatives, the formation of phosphomono- and diesters (both cyclic and acyclic) and oligosaccharide synthesis.
Place, publisher, year, edition, pages
Stockholm: Stockholms universitet , 1998. , 40 p.
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-45912ISBN: 91-7153-741-4OAI: oai:DiVA.org:su-45912DiVA: diva2:370337
1998-06-04, Magnélisalen, KÖL, Frescati, Stockholm, 10:00 (English)
Brimacombe, JS, Professor
Härtill fyra uppsatser.2010-11-162010-11-162010-11-16Bibliographically approved