Enantioselective synthesis of syn- and anti-1,3-aminoalcohols via β-aminoketones and subsequent reduction/dynamic kinetic asymmetric transformation
2010 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 132, no 43, 15182-15184 p.Article in journal (Refereed) Published
β-Aminoketones obtained from imines in an organocatalytic Mannich reaction were transformed to enantio- and diastereomerically pure 1,3-aminoalcohols with two stereogenic centers via a combined reduction/dynamic kinetic asymmetric transformation. Both syn and anti diastereomers were obtained in high yield, dr, and ee.
Place, publisher, year, edition, pages
2010. Vol. 132, no 43, 15182-15184 p.
IdentifiersURN: urn:nbn:se:su:diva-45969DOI: 10.1021/ja107857vISI: 000283621700029OAI: oai:DiVA.org:su-45969DiVA: diva2:370580
FunderSwedish Research CouncilKnut and Alice Wallenberg Foundation