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Receptor subtype selective galanin analogous for better understanding of the role of galanin in cancer progression
Stockholm University, Faculty of Science, Department of Neurochemistry.
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-6107-0844
2010 (English)Conference paper (Other academic)
Abstract [en]

Galanin and galanin receptors have been found in several tumors. Galanin signaling has been studied in more detail in small cell lung carcinoma, where signaling via the GalR2 decreases the tumor growth. Galanin has also been included in a clinical therapy for pancreatic tumor together with a somatostatin agonist and serotonin. However, galanin signals via three receptors subtype with a broad expression pattern. We have therefore, developed several subtype selective galanin analogous that should reduce the side effects caused by galanin treatment. Therefore, we hope that the successful design of galanin receptor subtype selective ligands increase the interest for galanin and cancer progression.

Place, publisher, year, edition, pages
National Category
Neurosciences Physiology
Research subject
Neurochemistry with Molecular Neurobiology
URN: urn:nbn:se:su:diva-45999OAI: diva2:370827
Keystone Symposia - Metabolism and Cancer Progression (X4), Vancouver, British Columbia Canada, March 12—17, 2010
Available from: 2011-01-14 Created: 2010-11-18 Last updated: 2015-04-21Bibliographically approved

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Runesson, JohanLangel, Ülo
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