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Mitochondrial accumulation of APP and Abeta: significance for Alzheimer disease pathogenesis.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2009 (English)In: Journal of cellular and molecular medicine, ISSN 1582-4934, Vol. 13, no 10, 4137-45 p.Article in journal (Refereed) Published
Abstract [en]

Accumulating evidence suggest that alterations in energy metabolism are among the earliest events that occur in the Alzheimer disease (AD) affected brain. Energy consumption is drastically decreased in the AD-affected regions of cerebral cortex and hippocampus pointing towards compromised mitochondrial function of neurons within specific brain regions. This is accompanied by an elevated production of reactive oxygen species contributing to increased rates of neuronal loss in the AD-affected brain regions. In this review, we will discuss the role of mitochondrial function and dysfunction in AD. We will focus on the consequences of amyloid precursor protein and amyloid-beta peptide accumulation in mitochondria and their involvement in AD pathogenesis.

Place, publisher, year, edition, pages
2009. Vol. 13, no 10, 4137-45 p.
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URN: urn:nbn:se:su:diva-46156DOI: 10.1111/j.1582-4934.2009.00892.xISI: 000274181900005PubMedID: 19725915OAI: oai:DiVA.org:su-46156DiVA: diva2:371819
Available from: 2010-11-22 Created: 2010-11-22 Last updated: 2010-12-17Bibliographically approved

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