The structure and conformation of saccharides determined by experiment and simulation
1997 (English)Doctoral thesis, comprehensive summary (Other academic)
A computer program, CASPER, for sequence determination of oligosaccharides and regular polysaccharides using NMR-data, has been extended to support multiply branched structures. The program has been modified to allow the use of incomplete experimental data since spectral overlap can be a problem even at high fields. The resulting program was tested and used in the structure determination of the capsular polysaccharide from Klebsiella type K52.
Four carboxyethyl-substituted sugars, methyl 4-O-[(R)- and (S)-1-carboxyethyl]-a-L-rhamnopyranoside and methyl 6-O-[(R)- and (S)-1-carboxyethyl]-a-D-galactopyranoside have been synthesized. The conformational properties of the latter two have been investigated by both NMR spectroscopy and molecular modelling studies. For the NMR-studies stereospecifically deuterated compounds were prepared.
Place, publisher, year, edition, pages
Stockholm: Stockholms universitet , 1997. , 32 p.
Other Basic Medicine
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-47334ISBN: 91-7153-611-6OAI: oai:DiVA.org:su-47334DiVA: diva2:373667
1997-05-16, Magnélisalen, Frescati, Stockholm, 10:00 (English)
Meyer, B., Professor
Härtill fem uppsatser.2010-12-012010-12-012010-12-01Bibliographically approved