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Pathways of mammalian replication fork restart
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
2010 (English)In: Nature reviews. Molecular cell biology, ISSN 1471-0072, Vol. 11, no 10, 683-687 p.Article, review/survey (Refereed) Published
Abstract [en]

Single-molecule analyses of DNA replication have greatly advanced our understanding of mammalian replication restart. Several proteins that are not part of the core replication machinery promote the efficient restart of replication forks that have been stalled by replication inhibitors, suggesting that bona fide fork restart pathways exist in mammalian cells. Different models of replication fork restart can be envisaged, based on the involvement of DNA helicases, nucleases, homologous recombination factors and the importance of DNA double-strand break formation.

Place, publisher, year, edition, pages
2010. Vol. 11, no 10, 683-687 p.
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Biological Sciences
URN: urn:nbn:se:su:diva-49135DOI: 10.1038/nrm2974ISI: 000282152800011OAI: diva2:376361
authorCount :2Available from: 2010-12-10 Created: 2010-12-10 Last updated: 2010-12-10Bibliographically approved

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Helleday, Thomas
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