Change search
ReferencesLink to record
Permanent link

Direct link
Physiological effects of diclofenac, ibuprofen and propranolol on Baltic Sea blue mussels
Stockholm University, Faculty of Science, Department of Systems Ecology.
Stockholm University, Faculty of Science, Department of Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Systems Ecology.
2010 (English)In: Aquatic Toxicology, ISSN 0166-445X, E-ISSN 1879-1514, Vol. 99, no 2, 223-231 p.Article in journal (Refereed) Published
Abstract [en]

Pharmaceuticals are constantly dispersed into the environment and little is known of the effects on non-target organisms. This is an issue of growing concern. In this study, Baltic Sea blue mussels, Mytilus edulis trossulus, were exposed to diclofenac, ibuprofen and propranolol, three pharmaceuticals that are produced and sold in large quantities and have a widespread occurrence in aquatic environments. The mussels were exposed to pharmaceuticals in concentrations ranging from 1 to 10,000 mu g l(-1). The pharmaceuticals were added both separately and in combination. Mussels exposed to high concentrations of pharmaceuticals showed a clear response compared to controls. Firstly, they had a significantly lower scope for growth, which indicates that the organisms had a smaller part of their energy available for normal metabolism, and secondly, they had lower byssus strength and lower abundance of byssus threads, resulting in reduced ability to attach to the underlying substrate. Mussels exposed to lower concentrations showed tendencies of the same results. The concentration of diclofenac and propranolol was quantified in the mussels using both liquid chromatography coupled to mass spectrometry (LC-MS). The measurements showed a significantly higher concentration in the organisms as compared to the water the mussels were exposed to; the uptake reached concentrations two orders of magnitudes higher than found in sewage treatment plant effluents. This study showed that common pharmaceuticals are taken up and negatively affect the physiology of a non-target species at levels of two to three orders of magnitudes higher than found in sewage treatment plant effluents.

Place, publisher, year, edition, pages
2010. Vol. 99, no 2, 223-231 p.
National Category
Biological Sciences
URN: urn:nbn:se:su:diva-49321DOI: 10.1016/j.aquatox.2010.04.017OAI: diva2:377150
Available from: 2010-12-13 Created: 2010-12-13 Last updated: 2014-02-27Bibliographically approved
In thesis
1. Pharmaecological perspectives: Exposure studies using coastal Baltic Sea organisms
Open this publication in new window or tab >>Pharmaecological perspectives: Exposure studies using coastal Baltic Sea organisms
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis investigates the effects of pharmaceutical substances on coastal Baltic Sea organisms. Despite an increasing awareness of the occurrence of pharmaceuticals in various aquatic compartments, current knowledge of their possible effects on non-target organisms is limited. Especially scarce is the knowledge concerning possible long-term effects, mixture-effects, effects on non-standard test organisms and indirect effects from interactions among organisms. Also the environmental fate, availability and distribution of pharmaceuticals between sediment, water and biota is only rarely investigated.

The aim of this thesis was therefore to investigate the biological effects of pharmaceuticals, and their distribution in organisms of a coastal Baltic Sea community. In four studies, blue mussels, amphipods and macroalgae were exposed to pharmaceuticals in laboratory experiments. The effects from exposure, as well as recovery from the same, were studied on different physiological variables. With increasing complexity of experiment designs, the tested substances were found to affect aquatic organisms from different hierarchical levels both through direct negative effects, as well as through indirect positive effects within model communities. Moreover, the studies showed that the organisms were affected by exposure to environmentally relevant concentrations, but also that exposed organisms could recover from the exposure. Effects from pharmaceutical mixtures occurred in lower concentrations than effects from single pharmaceutical substances, and high internal concentrations of two pharmaceuticals – diclofenac and propranolol – were detected in exposed organisms.

The detected effects and the uptake of pharmaceuticals in biota demonstrate a possible problem for aquatic environments, but especially for the Baltic Sea, since this is a naturally sensitive ecosystem with low species diversity, low functional redundancy and a history of heavy pollution.

Place, publisher, year, edition, pages
Stockholm: Department of Ecology, Environment and Plant Sciences, Stockholm Univeristy, 2014. 58 p.
Pharmaceuticals, Baltic Sea, Mytilus edulis trossulus, Fucus vesiculosus, Ceramium tenuicorne, Gammarus spp., Direct effects, Inter-specific interactions
National Category
Research subject
Marine Ecotoxicology
urn:nbn:se:su:diva-101160 (URN)978-91-7447-871-6 (ISBN)
Public defence
2014-04-04, Nordenskiöldsalen, Geovetenskapens hus, Svante Arrhenius väg 12, Stockholm, 13:30 (English)

At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Manuscript. Paper 4: Manuscript.

Available from: 2014-03-13 Created: 2014-02-27 Last updated: 2016-05-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Thorsen, GunnarKumblad, Linda
By organisation
Department of Systems EcologyDepartment of Analytical Chemistry
In the same journal
Aquatic Toxicology
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 164 hits
ReferencesLink to record
Permanent link

Direct link