Change search
ReferencesLink to record
Permanent link

Direct link
Microscopic implications of S-DNA
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2010 (English)In: Physical review. E, ISSN 1539-3755, Vol. 82, no 2, 21907- p.Article in journal (Refereed) Published
Abstract [en]

Recent experiments [J. van Mameren et al., Proc. Natl. Acad. Sci. U.S.A. 106, 18231 (2009)] provide a detailed spatial picture of overstretched DNA, showing that under certain conditions the two strands of the double helix separate at about 65 pN. It was proposed that this observation rules out the existence of an elongated, hybridized form of DNA (S-DNA). Here, we argue that the S-DNA picture is consistent with the observation of unpeeling during overstretching. We demonstrate that assuming the existence of S-DNA does not imply DNA overstretching to consist of the complete or near-complete conversion of the molecule from B to S form. Instead, this assumption implies in general a more complex dynamic coexistence of hybridized and unhybridized forms of DNA. We argue that such coexistence can rationalize several recent experimental observations.

Place, publisher, year, edition, pages
2010. Vol. 82, no 2, 21907- p.
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:su:diva-49460DOI: 10.1103/PhysRevE.82.021907ISI: 000280757700005OAI: diva2:378143
authorCount :3Available from: 2010-12-15 Created: 2010-12-14 Last updated: 2010-12-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Pronk, Sander
By organisation
Department of Biochemistry and Biophysics
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 13 hits
ReferencesLink to record
Permanent link

Direct link