Coenzyme Q - Biosynthesis and functions
2010 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 396, no 1, 74-79 p.Article in journal (Refereed) Published
In addition to its role as a component of the mitochondrial respiratory chain and our only lipid-soluble antioxidant synthesized endogenously, in recent years coenzyme Q (CoQ) has been found to have an increasing number of other important functions required for normal metabolic processes. A number of genetic mutations that reduce CoQ biosynthesis are associated with serious functional disturbances that can be eliminated by dietary administration of this lipid, making CoQ deficiencies the only mitochondrial diseases which can be successfully treated at present. In connection with certain other diseases associated with excessive oxidative stress, the level of CoQ is elevated as a protective response. Aging, certain experimental conditions and several human diseases reduce this level, resulting in serious metabolic disturbances. Since dietary uptake of this lipid is limited, up-regulation of its biosynthetic pathway is of considerable clinical interest. One approach for this purpose is administration of epoxidated all-trans polyisoprenoids, which enhance both CoQ biosynthesis and levels in experimental systems.
Place, publisher, year, edition, pages
2010. Vol. 396, no 1, 74-79 p.
Coenzyme Q, Mevalonate pathway, Metabolic regulators, Mitochondrial diseases
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:su:diva-49914DOI: 10.1016/j.bbrc.2010.02.147ISI: 000278251800015OAI: oai:DiVA.org:su-49914DiVA: diva2:380274
authorCount :32010-12-212010-12-202010-12-21Bibliographically approved