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Asymmetric synthesis of Maraviroc (UK-427,857)
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
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2010 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 352, no 13, 2291-2298 p.Article in journal (Refereed) Published
Abstract [en]

The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral β-amino aldehyde key fragment is presented. The reactions were performed on a gram-scale and allow for the rapid construction of new Maraviroc analogues.

Place, publisher, year, edition, pages
Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA , 2010. Vol. 352, no 13, 2291-2298 p.
Keyword [en]
β-amino aldehydes, asymmetric catalysis, conjugate additions, Maraviroc, ring-opening
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:su:diva-50332DOI: 10.1002/adsc.201000287ISI: 000282621700027OAI: oai:DiVA.org:su-50332DiVA: diva2:380785
Available from: 2010-12-22 Created: 2010-12-22 Last updated: 2017-12-11Bibliographically approved

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Zhao, Gui-LingLin, ShuangzhengDeiana, LucaCórdova, Armando
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