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Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia
Stockholm University, Faculty of Social Sciences, Department of Psychology.
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2010 (English)In: Progress in Neuro-psychopharmacology and Biological Psychiatry, ISSN 0278-5846, E-ISSN 1878-4216, Vol. 34, no 6, 1094-1097 p.Article, review/survey (Refereed) Published
Abstract [en]

The early development of dopaminergic pathways has been attributed importance for the aetiology of schizophrenia. Several transcription factors are involved in the survival and maturation of dopamine neurons, including LMX1A, LMX1B and PITX3. The possibility that polymorphisms in these genes may influence the development and/or the maintenance of dopaminergic neurons prompted us to investigate if five single nucleotide polymorphisms (SNPs) previously linked to Parkinson's disease are associated with this disorder. Preliminary evidence that genetic variation in LMX1A (rs6668493, rs4657411), LMX1B (rs10987386) and PITX3 (rs4919621) may increase the risk of developing schizophrenia is presented.

Place, publisher, year, edition, pages
2010. Vol. 34, no 6, 1094-1097 p.
Keyword [en]
LMX1A, LMX1B, Neurodevelopment, PITX3, Schizophrenia
National Category
Psychology
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-50084DOI: 10.1016/j.pnpbp.2010.05.032ISI: 000281187800044OAI: oai:DiVA.org:su-50084DiVA: diva2:382320
Note
authorCount :5Available from: 2010-12-30 Created: 2010-12-21 Last updated: 2017-12-11Bibliographically approved

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