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Influence of DMSO on Carbon K ultrasoft X-rays induced chromosome aberrations in V79 Chinese hamster cells
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2010 (English)In: Mutation research, ISSN 0027-5107, E-ISSN 1873-135X, Vol. 691, no 02-jan, 23-26 p.Article in journal (Refereed) Published
Abstract [en]

Ultrasoft X-rays have been shown to be very efficient in inducing chromosomal aberrations in mammalian cells. The present study was aimed to evaluate the modifying effects of DMSO (a potent scavenger of free radicals) on the frequencies of chromosome aberrations induced by soft X-rays. Confluent held G1 Chinese hamster cells (V79) were irradiated with Carbon K ultrasoft X-rays in the presence and absence of 1 M DMSO and frequencies of chromosome aberrations in the first division cells were determined. DMSO reduced the frequencies of exchange types of aberrations (dicentrics and centric rings) by a factor of 2.1-3.5. The results indicate that free radicals induced by ultrasoft X-rays contribute to a great extent to the induction of chromosome aberrations. The possible implications of these results in interpreting the mechanisms involved in the high efficiency of ultrasoft X-rays in the induction of chromosome aberrations are discussed.

Place, publisher, year, edition, pages
2010. Vol. 691, no 02-jan, 23-26 p.
Keyword [en]
Chromosome aberrations, Ultrasoft X-rays, DMSO
National Category
Natural Sciences
URN: urn:nbn:se:su:diva-50075DOI: 10.1016/j.mrfmmm.2010.06.008ISI: 000282348900004OAI: diva2:382694
authorCount :5Available from: 2011-01-03 Created: 2010-12-21 Last updated: 2011-01-03Bibliographically approved

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Department of Genetics, Microbiology and Toxicology
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