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4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2010 (English)In: Nature chemical biology, ISSN 1552-4450, Vol. 6, no 7, 515-517 p.Article in journal (Refereed) Published
Abstract [en]

Coenzyme Q (Q) is an electron transporter in the respiratory chain and a lipid-soluble antioxidant that decreases in humans with age. Here we show that 4-nitrobenzoate inhibited 4-hydroxybenzoate: polyprenyl transferase (Coq2) in a competitive manner and dose-dependently decreased Q in mammalian cells without accumulation of Q intermediates. As 4-nitrobenzoate neither interfered with mitochondrial respiration nor induced oxidative stress, it should prove a valuable tool for studies on both Q deficiency and Q supplementation.

Place, publisher, year, edition, pages
2010. Vol. 6, no 7, 515-517 p.
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Natural Sciences
Identifiers
URN: urn:nbn:se:su:diva-50654DOI: 10.1038/NCHEMBIO.372ISI: 000278878700011OAI: oai:DiVA.org:su-50654DiVA: diva2:383219
Note
authorCount :4Available from: 2011-01-04 Created: 2010-12-30 Last updated: 2011-01-04Bibliographically approved

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