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NordicDB: a Nordic pool and portal for genome-wide control data
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2010 (English)In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 18, no 12, 1322-1326 p.Article in journal (Refereed) Published
Abstract [en]

A cost-efficient way to increase power in a genetic association study is to pool controls from different sources. The genotyping effort can then be directed to large case series. The Nordic Control database, NordicDB, has been set up as a unique resource in the Nordic area and the data are available for authorized users through the web portal (http://www.nordicdb.org). The current version of NordicDB pools together high-density genome-wide SNP information from similar to 5000 controls originating from Finnish, Swedish and Danish studies and shows country-specific allele frequencies for SNP markers. The genetic homogeneity of the samples was investigated using multidimensional scaling (MDS) analysis and pairwise allele frequency differences between the studies. The plot of the first two MDS components showed excellent resemblance to the geographical placement of the samples, with a clear NW-SE gradient. We advise researchers to assess the impact of population structure when incorporating NordicDB controls in association studies. This harmonized Nordic database presents a unique genome-wide resource for future genetic association studies in the Nordic countries. European Journal of Human Genetics (2010) 18, 1322-1326; doi: 10.1038/ejhg.2010.112; published online 28 July 2010

Place, publisher, year, edition, pages
2010. Vol. 18, no 12, 1322-1326 p.
Keyword [en]
common controls, genome-wide data, Nordic Control Database, population stratification
National Category
Mathematics
Identifiers
URN: urn:nbn:se:su:diva-51344DOI: 10.1038/ejhg.2010.112ISI: 000284376800010OAI: oai:DiVA.org:su-51344DiVA: diva2:384931
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authorCount :19Available from: 2011-01-10 Created: 2011-01-10 Last updated: 2017-12-11Bibliographically approved

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Palmgren, Juni
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