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Analytical description of the LET dependence of cell survival using the repairable-conditionally repairable damage model
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI). RaySearch Laboratories, Sweden.
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).ORCID iD: 0000-0002-7101-240X
RaySearch Laboratories, Sweden.
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2010 (English)In: Radiation Research, ISSN 0033-7587, E-ISSN 1938-5404, Vol. 174, no 4, 517-525 p.Article in journal (Refereed) Published
Abstract [en]

In light-ion radiation therapy, both the dose and the local energy spectrum, which is often characterized with the linear energy transfer (LET), must be considered. In treatment optimization, it is advantageous to use a radiobiological model that analytically accounts for both dose and LET for the ion type of interest. With such a model the biological effect can also be estimated for dose and LET combinations for which there are no observations in the underlying experimental data. In this study, the repairable-conditionally repairable (RCR) damage model was extended by expressing its parameters as functions of LET to provide a radiobiological model that accounts for both the dose and the LET for a given ion type and cell line. This LET-parameterized RCR model was fitted to published cell survival data for HSG and V79 cells irradiated with carbon ions and for T1 cells irradiated with helium ions. To test the robustness of the model, fittings to only a subset of the data were performed. Good agreement with the cell survival data was obtained, including survival data for LET values not used for model fitting, opening up the possibility of using the model in treatment planning for light ions.

Place, publisher, year, edition, pages
2010. Vol. 174, no 4, 517-525 p.
National Category
Cancer and Oncology Biological Sciences Biophysics Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:su:diva-51749DOI: 10.1667/RR2045.1ISI: 000282542200011OAI: oai:DiVA.org:su-51749DiVA: diva2:386047
Note

authorCount :5

Available from: 2011-01-12 Created: 2011-01-12 Last updated: 2017-12-11Bibliographically approved

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Toma-Dasu, Iuliana
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